In this meta-analysis, Fig 9 showed that the cumulative Z-curve of all the H19 mutations investigated either crossed the trial sequential monitoring boundary or exceeded the required information size, indicating that the results about the associations between LncRNA H19 polymorphic variants (rs2839698 G>A, rs217727 G>A, rs2107425 C>T, rs2735971 A>G and rs3024270 C>G) and the susceptibility to cancer were firm evidence of effect. This evidence concerns the gene H19 and cancer.