To conclude, the results of this meta-analysis revealed that five H19 polymorphisms (rs2839698 G>A, rs217727 G>A, rs2107425 C>T, rs2735971 A>G and rs3024270 C>G) had no significant association with the overall cancer susceptibility, thereby suggesting that H19 might be not qualified for the ideal marker in the diagnosis and treatment of cancer. This evidence concerns the gene H19 and cancer.