The Alere LAM test sensitivity remains best for HIV-positive inpatients, with signs and symptoms of TB, and CD4+ T-cell counts ≤100 cells/μL, 61% (95%CI 40–78%), but significantly lower in patients with higher CD4+ T-cell counts–the pooled sensitivity for patients with CD4+ T-cell counts >200 was found to be 16% (95%CI 8–31%) [6]. This evidence concerns the gene CD4 and tuberculosis.