A study showed that in leukemia cells, decreased FTO expression can increase the level of m6A methylation in mRNA of the key enzyme of glycolysis, while reading protein YTHDF2 reduces the translation and expression of LDHB, a key enzyme in glycolysis, by promoting mRNA degradation, thereby inhibiting aerobic glycolysis and cell proliferation [41, 42]. The gene discussed is YTHDF2; the disease is leukemia.