A kinetic study of antigen presentation by DC‐like DC2.4 cell line provided compelling evidence for the DRiP hypothesis: Focused on eight of the 49 epitopes recognised by VACV immune CD8+ T cells, these peptides were quantified over a 12.5‐h infection period in a highly sensitive MRM (multiple reaction monitoring) mass spectrometry experiment. This evidence concerns the gene CD8A and infection.