Indeed, SNCA expression in excitatory neurons from the Lewy body dementias, as compared with the control group, was marked by (i) a decrease in the proportion of SNCA-expressing nuclei in PDD and (ii) a shift in the expression range of the top 10% highest expressing nuclei to lower levels of SNCA expression (Fig. 4c). Here, SNCA is linked to Lewy body dementia.