In support of this observation, expression of SNCA (encoding α-synuclein, the major component of Lewy bodies [102]) in excitatory neurons from the Lewy body dementias, as compared with the control group, was marked by a decrease in the proportion of SNCA-expressing nuclei in PDD and a shift in the expression range of the top 10% highest expressing nuclei to lower values. This evidence concerns the gene SNCA and Lewy body dementia.