Induction of miR-200 in tumor cells by different means pushes the cells to a more epithelial state, which is generally considered a less aggressive phenotype for tumor cells and more akin to a “normal” cell state, with expression of p21 and restoration of the cell cycle checkpoint that is lost or blunted in mesenchymal-like tumor cells with high ZEB1 activity. This evidence concerns the gene ZEB1 and neoplasm.