NF1 and von Hippel-Lindau disease: Classical syndromic associations include von Hippel–Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN2), and neurofibromatosis type 1 (NF1), due to pathogenic variants in VHL, RET, and NF1; and familial PGL syndromes types 1–5, associated with pathogenic variants in SDHD, SDHAF2, SDHC, SDHB, and SDHA, respectively.