In summary, the glomerular and tubulo-interstitial changes seen in HIV-Tg26 mice injected with rAd-FGF-2 vectors were similar to those seen in HIV-Tg26 mice that developed HIVAN spontaneously (Fig. S1) and in children with HIVAN (Fig. 7C). This evidence concerns the gene FGF2 and HIV-associated nephropathy.