Also, key componentsof the excitation-contraction complex were similarlyexpressed in patients and healthy differentiated CM.Notably, the expression level of MYH6, MYH7 and MYL2was increased in S1-CM and the MYH6/MYH7 ratio waslower in both patient-derived CM compared to C2-CMwhich may indicate more mature phenotype of SSc iPSC-derived CM; however, the similar functional propertieswere found in all cardiomyocytes. The gene discussed is MYH7; the disease is systemic sclerosis.