Multiple mechanisms are involved in VE-cadherinregulation including Twist/Slug/Snail family which aretranscriptional repressors of VE-cadherin gene (34).Lopez et al. (34) investigated the cause of VE-cadherindownregulation in ECs exposed to breast cancer cells-conditioned media and found direct repression of VE-cadherin promoter by Twist/Slug/Snail family. The gene discussed is CDH5; the disease is breast cancer.