For example, in RCC (including chromophobe carcinoma, ccRCC, and papillary cell carcinoma), low expression of HDAC1, HDAC2, HDAC3, HDAC8, HDAC10 and high expression of HDAC5, HDAC7, HDAC11 have longer survival time. The gene discussed is HDAC8; the disease is nonpapillary renal cell carcinoma.