APOE and Alzheimer disease: Among the three 10-year models with AD as an outcome, c statistics were 0.70 for the simple model by Verhaaren et al. [32] (a) that included age + sex/gender, 0.73 for the model by Verhaaren et al. [32] (b) that included the simple model + APOE e4, and 0.76 for the 2005 model by Tierney et al. [33].