Notably, 10 out of the 38 gene variants in epilepsy patients were related to synaptic signaling pathways, including cholinergic synaptic signaling (CHRNA4, KCNQ1, KCNQ2, and KCNQ3), dopaminergic synaptic signaling (GRIN2A, GRIN2B, and SCN1A), and GABAergic synaptic signaling (GABRA1, GABRB3, and GABRG2) (Helbig et al., 2018, Helbig et al., 2016). The gene discussed is CHRNA4; the disease is epilepsy.