In addition, there are other positive effects of SGLT2 inhibitors on HF hemodynamics that may be independent of DM, such as natriuresis and preload reduction; beneficial effects on circulating provascular progenitor cells; blood pressure lowering and afterload reduction; and regression of left ventricular hypertrophy [41], [42], [43]. The gene discussed is SLC5A2; the disease is left ventricular hypertrophy.