Interestingly, by analyzing gene expression data sets from 170 newly diagnosed, uniformly treated MM patients, Song et al.[51] reported that the 19S subunit Rpn11, a deubiquitinating enzyme (DUB), is more highly expressed in patient MM cells than in normal plasma cells and its expression is directly correlated with poor patient survival. The gene discussed is ZUP1; the disease is Miyoshi myopathy.