These can be divided into disorders resulting from mutations affecting the early stages of autophagy, such as neurodegeneration with brain iron accumulation and hereditary spastic paraplegia 49 (SPG49), and those caused by mutations affecting later stages of the autophagy pathway, including hereditary spastic paraplegias 11 (SPG11) and 15 (SPG15), Vici Syndrome, and SNX14-associated ataxia. This evidence concerns the gene ZFYVE26 and hereditary spastic paraplegia.