INS and diabetes mellitus: Several studies have suggested that there is an association between DM and TB and the possible interlink represent an important and growing challenge of TB global control.14 Conversely, Active TB patients experience Inflammation caused by cytokines such as IL6 and TNFa in response to TB infection which may cause an increase in insulin resistance and decreased insulin production, thereby leading to hyperglycemia.15 Additionally, isoniazid and rifampin have hyperglycaemic effects.