CASP3 and B-cell chronic lymphocytic leukemia: Moreover, acacetin has been shown to target mitochondria to induce apoptosis of chronic lymphocytic leukemia (CLL) B lymphocytes through increased reactive oxygen species formation, mitochondrial membrane potential collapse, mitochondrial permeability transition, release of cytochrome c, caspase 3 activation, and finally apoptosis, whereas normal healthy B lymphocytes were unaffected.