INS and type 2 diabetes mellitus: Compared to the mice fed a standard fat diet, the HFD-induced type 2 diabetic mice exhibited an obvious increase in body weight (Figure 2(a)), as well as hyperglycemia (Figure 2(b)), insulin resistance characterized by decreased glucose intolerance (Figures 2(c) and 2(d)), insulin sensitivity (Figures 2(e) and 2(f)), and increased serum insulin (Figure 2(g)).