BRAF and thyroid gland disorder: Similarly, we found that the risk of central neck lymph node metastasis in male patients was 2.564 times higher than that in female, and the risk in patients with thyroid extracapsular invasion was 2.956 times higher than that in patients with intact capsule, suggesting that BRAF V600E mutation was not the only cause of central neck lymph node metastasis, so that it cannot be used independently to predict the risk of central neck lymph node metastasis but can just be used as a reference indicator of neck lymph node metastasis.