Although it can be hypothesized that in IDD patients, the NEAT1–miR-5100–COL10A1 interaction axis may be unbalanced, leading to the occurrence of IDD; there is still a lack of evidence that NEAT1 can negatively regulate miR-5100 and thereby regulate COL10A1 to realize ECM remodelling. Here, NEAT1 is linked to intervertebral disk degenerative disorder.