EGFR and cholangiocarcinoma: Homologs of some of these alterations are clinically actionable in humans; for example, both the plasma and the tissue of a cholangiocarcinoma patient (PT02) featured an EGFR p.L805R mutation, which is homologous to the human EGFR p.L858R mutation, a common target for EGFR tyrosine kinase inhibitors (27).