Notably, a marked decrease in the expression of nuclear Cavβ2 in the left ventricle was associated with the development of cardiac hypertrophy after TAC (Figure 4A), while the levels of membrane-associated Cavβ2 in the left ventricle and of nuclear Cavβ2 in the right ventricle were unaltered (Figures 4B,C). The gene discussed is CACNB2; the disease is cardiac hypertrophy.