In addition, MKK6 and TP53RK, the potential targets of miR-30d-3p and miR-140-3p, were up-regulated in atherosclerotic vessels and oxidative-stress damaged endothelial cells, further suggesting that circRNA KHDRBS1 and circRNA ABCA1 may regulate vascular endothelial injury and atherosclerosis through the ceRNA mechanism. The gene discussed is TP53RK; the disease is atherosclerosis.