Besides, cytokine-cytokine receptor interaction signaling pathway, calcium signaling, TGF-β signaling pathway, Jak-STAT signaling pathway, focal adhesion signaling pathway, HIF-1signaling pathway may also be potential pathways for differentially expressed circRNAs to regulate the pathological process of endothelial injury and atherosclerosis (Figure 7). This evidence concerns the gene TGFB1 and atherosclerosis.