SHH and amyotrophic lateral sclerosis: For example, a study found that, in the spinal cord of mutant superoxide dismutase mice, the key markers of Notch signaling pathway change with age, and this trend is positively correlated with the change of the SHH signaling pathway, indicating that the association of these two pathways in vivo may contribute to dysfunction and death of motor neurons in ALS (Ma et al., 2017).