Loss of SARM1 has been shown to protect mice from peripheral neuropathies (Geisler et al., 2016; Turkiew et al., 2017) and TBI-induced axon loss (Henninger et al., 2016), although there is still a debate on the contribution of SARM1 to ALS (Fogh et al., 2014; Veriepe et al., 2015; Peters et al., 2018). Here, SARM1 is linked to amyotrophic lateral sclerosis.