We used the CCLE databases to probe the mRNA expression of Arp2/3 subunits in HCC cell lines and found that Arp2/3 subunits were widely expressed in 23 HCC cell lines; among them, the expression levels of ACTR2 and ARPC3 were higher than those of other subunits, and the ARPC5L expression level was lowest in HCC cell lines (Figure 4). The gene discussed is ACTR2; the disease is hepatocellular carcinoma.