We found that higher expression of ARP 2/3 subunits was associated with worse OS, and overexpression of ACTR2, ACTR3, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, and ARPC5L was related to shorter PFS in HCC. The gene discussed is ARPC1A; the disease is hepatocellular carcinoma.