Using gene set enrichment analysis (GSEA), this study found that Arp2/3 subunits mainly participate in regulating various cancer pathways, including colorectal cancer, pancreatic cancer, bladder cancer, lung cancer, renal cell carcinoma, and the VEGF, MAPK, and Wnt signaling pathways. The gene discussed is VEGFA; the disease is hereditary clear cell renal cell carcinoma.