The results of univariate Cox regression analysis showed that the Arp2/3 subunits (ACTR2, ACTR3, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, and ARPC5L) and the clinical stage were associated with poor survival outcomes in HCC patients. This evidence concerns the gene ACTR2 and hepatocellular carcinoma.