The results of univariate Cox regression analysis showed that the Arp2/3 subunits (ACTR2, ACTR3, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, and ARPC5L) and the clinical stage were associated with poor survival outcomes in HCC patients. The gene discussed is ARPC3; the disease is hepatocellular carcinoma.