According to the GSEA results, high expression of ACTR3 was positively related to 82 gene sets at FDR <0.01, the functions of which focused on regulation of the actin cytoskeleton, protein ubiquitination, the immune system process, genesis and progression of various tumors, leukocyte migration, and the DNA metabolic process; the ACTR3 overexpression was closely relevant to the “JAK-STAT signaling pathway,” the “WNT signaling pathway,” the “pathway in cancer,” the “VEGF signaling pathway,” “non–small-cell lung cancer,” “pancreatic cancer,” and “renal cell carcinoma,” as shown in Figure 13A. Here, VEGFA is linked to hereditary clear cell renal cell carcinoma.