Meanwhile, plasma HSP90α levels were significantly higher than healthy controls in other cancers, but the diagnostic efficiency was insufficient, such as gastric cancer, breast cancer, nasopharyngeal carcinoma and colorectal cancer (Kasanga et al., 2018; Liu et al., 2019; Lin et al., 2020; Zhang et al., 2020). The gene discussed is HSP90AA1; the disease is breast cancer.