APOB and hypoparathyroidism-retardation-dysmorphism syndrome: Based on previous studies, signature 3 was associated with homologous recombination deficiency (HRD), signature 13 was associated with the activation of apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC), and signature 16 was related to alcohol and transcription-coupled damage (Letouzé et al., 2017).