In glioma, recent studies have reported that immunotherapy such as anti-PD-1 and anti-VEGFA could predominantly prolong the survival of some glioma patients, but the response population was not stable, only a subset of patients could benefit from immunotherapy (Sandmann et al., 2015; Lyon et al., 2017; Schalper et al., 2019). This evidence concerns the gene VEGFA and central nervous system cancer.