On the contrary, knocking down the expression of Mettl3 could inhibit the viability, proliferation, and migration potential of HK2 cells and, thus, attenuate the TGF-β1–induced epithelial–mesenchymal transition (EMT), suggesting that Mettl3 might play a detrimental role in the process of renal fibrosis (Liu P. et al., 2020). This evidence concerns the gene TGFB1 and renal fibrosis.