Well-known features of CCM pathobiology such as actin stress fiber formation, disruption of the integrity of intercellular junctions or upregulation of the transcription factors KLF2 and KLF4 (Glading et al., 2007; Schneider et al., 2011; Faurobert et al., 2013; Shenkar et al., 2015; Cuttano et al., 2016; Zhou et al., 2016) were recapitulated in this cell culture model. Here, KLF2 is linked to cerebral cavernous malformation.