ADAM17 and type 2 diabetes mellitus: Despite there are few data about sCD163 in human diabetic nephropathy some studies described that sCD163 levels were also strongly associated with later development of type 2 diabetes in both lean and obese subjects, likely reflecting macrophage recruitment in the adipose tissue (117, 139–143) and in the liver (144–146), an effect associated to ADAM17/TACE-mediated shedding of TNF-α and sCD163 (116).