Moreover, at univariate analysis the following clinical and laboratory manifestations during flares did not affect complete response: thoracic pain (p = 0.44), skin rash (p = 0.21), pericarditis (p = 0.16), pleuritis (p = 0.80), abdominal pain (p = 0.96), myalgia (p = 0.86), arthritis (p = 0.66), lymphadenitis (p = 0.66), ESR levels (p = 0.91), CRP levels (p = 0.94), SAA levels (p = 0.99). This evidence concerns the gene CRP and lymphadenitis.