In conclusion, through the clinical sample MeRIP-seq combined with MsigDB database and TGCA database data mining, we determined that CD34/CD276 can be combined as a molecular marker for predicting the viability inpatients with CRC, which may promote the immune microenvironment remodeling of CRC and ultimately promote immune escape by relying on the down-regulation of m6A modification. The gene discussed is CD276; the disease is colorectal carcinoma.