TNFSF11 and osteoporosis: Artemisinin (ARS) and its related compounds, which are already known as inhibitors of osteoporosis due to their suppression of osteoclast differentiation by blocking the receptor activator of nuclear factor kappa-B ligand (RANKL) pathway, may induce ferroptosis in osteoclasts due to the high levels of ferritin and LIP in osteoclasts (Zhang, 2020).