GCH1 and metabolic disease: Strikingly, a new study unveiled that glucose starvation-induced energy stress significantly attenuated erastin- and cysteine/GPX4 depletion-induced ferroptosis due to AMP-activated protein kinase (AMPK) in immortalized mouse embryonic fibroblasts (Lee et al., 2020); whereas, activation of AMPK is verified to recede T2DM-induced BH4 reduction by preventing GCH1 degradation, further intimating about the potential role of ferroptosis in metabolic diseases (Day et al., 2017).