INS and endocrine system disorder: Intriguingly, as the micronutrient, selenium (Se) and selenoprotein are integral in several metabolic and endocrine diseases, such as thyroid disease and diabetes, and raising their level has been relevant to insulin-induced, hydrogen peroxide (H2O2)-dependent signaling impairment, resulting in insulin resistance and hyperglycemia (Wang et al., 2016; Kim et al., 2019; Schomburg, 2020).