ACE2 and liver dysplastic nodule: Controversially, Nrf2 has a dual effect in diabetes and its complications, such as DN (Xu J. et al., 2012; Uruno et al., 2013), and upregulation of Nrf2 appears to block ferroptosis to delay the progression of DN (Li S. et al., 2021) while it may also attenuate DN by augmenting the expression of intrarenal angiotensin-converting enzyme-2 and angiotensin 1–7 receptor (Zhao et al., 2018).