In addition, researchers have identified a gene, pyruvate dehydrogenase kinase 4 (PDK4), that is obligated to alter ferroptosis sensitivity in human pancreatic ductal carcinoma cells through the system Xc–, influenced by glucose metabolism, implicating a new view of cancer therapy (Song et al., 2021). The gene discussed is PDK4; the disease is pancreatic ductal adenocarcinoma.