In summary, this study indicated that knockdown of ox-LDL-induced or atherosclerosis-increased lncRNA NORAD aggravated VEGF expression to ameliorate vascular endothelial cell injury and atherosclerosis development, and nucleus lncRNA NORAD suppressed VEGF transcription through enhancing H3K9 deacetylation via recruiting HDAC6 to the VEGF gene promoter in ox-LDL-treated HUVECs. Here, NORAD is linked to atherosclerosis.