Except for nucleus lncRNA NORAD and HDAC6, cytoplasmic lncRNA NORAD and HDAC6 may also play a suppressive role in VEGF expression through associating with VEGF protein and subsequently enhancing the deacetylation of VEGF protein in vascular endothelial cell injury, atherosclerosis, and CAD. The gene discussed is HDAC6; the disease is coronary artery disorder.