NR3C1 and ovarian cancer: The activation of glucocorticoid receptors can also upregulate the expression of serum and glucocorticoid-regulated kinase 1 (SGK1) and MKP-1, both of which can promote the survival of ovarian cancer cells (Melhem et al., 2009; Stringer-Reasor et al., 2015) (Figure 3A).