Norepinephrine and E induce Nf-kb phosphorylation through ADRB2, and then p-Nf-kb enters the nucleus and binds with the PTGS2/PTGES gene to increase the synthesis of PGE2, which ultimately drives the proliferation and metastasis of ovarian cancer (Nagaraja et al., 2016). This evidence concerns the gene ADRB2 and ovarian cancer.