ADRB2 and ovarian carcinoma: Norepinephrine and E induce Nf-kb phosphorylation through ADRB2, and then p-Nf-kb enters the nucleus and binds with the PTGS2/PTGES gene to increase the synthesis of PGE2, which ultimately drives the proliferation and metastasis of ovarian cancer (Nagaraja et al., 2016).