The urokinase receptor (uPAR) regulates tumor growth by controlling β1 integrin signaling which drives a cascade of Ras/ERK mitogenic activation via the focal adhesion kinase (FAK) and the EGF receptor (EGFR) (Aguirre Ghiso et al., 1999; Aguirre Ghiso, 2002; Liu et al., 2002; White et al., 2004). The gene discussed is PLAUR; the disease is neoplasm.