Furthermore, mutations in MUC4, a gene involved in angiogenesis and metastasis (Zhi et al., 2014), were specifically enriched in stomach adenocarcinoma, while EGFR, FAT3/4, LRP1B, KAT6B mutations, mainly linked with cell proliferation and immune responses (Katoh, 2012; Simó-Riudalbas et al., 2015; Sigismund et al., 2018; Chen et al., 2019), were depleted in colon cancer (Fisher’s exact test adjusted p < 0.05, Supplementary Figure 11). This evidence concerns the gene FAT3 and gastric adenocarcinoma.