TP53 and neoplasm: The genes presenting a depletion of point mutations within dormant samples identified by our analysis have key functions in regulating tumor growth, including TP53, the master regulator that coordinates signals of stress such as DNA damage and aberrant growth signaling and can induce cell cycle arrest or apoptosis (Polyak et al., 1997; Vogelstein et al., 2000), or APC, which suppresses tumor growth through repression of the Wnt signaling pathway (Boman and Fields, 2013).