While prior research has highlighted HIF-1α expression as a promoter of angiogenesis and tumor invasion in bladder carcinoma (Theodoropoulos et al., 2004) and metastasis in uveal melanoma (Asnaghi et al., 2014), our analysis suggests that a period of TMD-induced latency may also be compatible with hypoxia in these cancers. The gene discussed is HIF1A; the disease is urinary bladder carcinoma.