REN and neoplasm: The results showed that multiple tumor-related pathways, including P53 signaling pathway, DNA replication, Cell cycle, and Base excision repair were enriched in the C1 subtype, while the metabolism-related pathways such as Fatty acid metabolism, Primary bile acid biosynthesis, Renin angiotensin system and Tyrosine metabolism were enriched in C2 (Figures 4D,E).