Moreover, sentrin/SUMO-SPECIFIC PROTEASE 7 is significantly upregulated in patients with SLE (Cui Y. et al., 2017), and levels of the METTL3 mRNA are significantly decreased in the peripheral blood of patients with SLE compared with healthy controls (Luo et al., 2020a). The gene discussed is METTL3; the disease is systemic lupus erythematosus.