XPO1 and celiac disease: Wang et al. (2017) found that NSun2 methylates the IL-17A mRNA at cytosine C466 in vitro and in vivo, which promotes the translation of IL-17. Evidence has shown that m6A RNA methylation participates in coeliac disease, a complex autoimmune disorder (Olazagoitia-Garmendia et al., 2021). Higher m6A methylation in the 5′ UTR of the XPO1 RNA results in increased XPO1 protein concentrations that lead to nuclear factor kappa B activation and inflammation (Wang et al., 2017).