Evidence also shows that the production of type 1 interferon (IFN I), the most important cytokine involved in SLE pathogenesis, its production triggered by dsDNA or human cytomegalovirus is controlled by cellular METTL14 and ALKBH5 demethylases (Rubio et al., 2018). The gene discussed is ALKBH5; the disease is systemic lupus erythematosus.