However, Foretinib also activated other pathways in MC38 cells, such as the AKT/mTOR and MAPK pathways (data not shown), which have been associated with the expression of PD-L1, however, these pathways were inhibited in other tumor cells, such as human colon cancer cell line KM12SM, human esophageal adenocarcinoma cell line OE33, human gastric cancer cell line MKN45 and human lung carcinoma cell lines NCI-H1993 (Liu et al., 2011; Goltsov et al., 2018; Nishiyama et al., 2018; Sohn et al., 2020). The gene discussed is AKT1; the disease is malignant colon neoplasm.