Moreover, the levels of PD-L1 in the CT26 tumor tissues were determined by western blotting after Foretinib treatment, which demonstrated that PD-L1, p-JAK2 and p-STAT1 (included S727 and Y701) were significantly increased (Supplementary Figure 7), which was similar to the MC38 tumor (Figures 1J,K). This evidence concerns the gene CD274 and neoplasm.