Moreover, the genes associated with T cell function (e.g., perforin and IFN-γ) and T cell recruitment (e.g., CCL5) (Supplementary Figures 5A,B) were enriched within the tumor and the level of IFN-γ and TNF-α (Supplementary Figures 5C,D) in plasma after treatments was elevated, especially following the combined treatment. This evidence concerns the gene IFNG and neoplasm.