It is clear that TAMs play a pivotal role in tumor progression and resistance to the effects of PD-1 blockade (Biswas and Mantovani, 2010; Lewis et al., 2016; Mantovani and Locati, 2016), which is closely associated with a poor prognosis (Asgharzadeh et al., 2012; Koromilas and Sexl, 2013; Hambardzumyan et al., 2016). Here, PDCD1 is linked to neoplasm.