Further supporting the speculation that abnormal ER-phagy is involved in the development of neurological diseases is that RTN3-immunoreactive dystrophic neurites (RIDNs) and the accumulation of high-molecular-weight RTN3 in patients with AD cases and mouse models result in neuronal dystrophy, which eventually leads to impairments in spatial learning and memory (Hu et al., 2007). The gene discussed is RTN3; the disease is nervous system disorder.