NLRP3 and atherosclerosis: In vitro experiments have shown that lectin-type oxidized LDL receptor 1 (LOX-1), the main receptor for ox-LDL, expressed in response to lipopolysaccharide (LPS) induction, can lead to ROS production, mtDNA damage (Figure 2B), and the production of NLRP3 inflammasomes and play an important role in inflammatory diseases such as atherosclerosis (Ding et al., 2014).