More importantly, rescue assays revealed that JaK2 expression could be positively regulated through the exosomal circ_0000337/miR-377-3p in esophageal cancer cells, further verifying that exosomal circ_0000337 might exert the biological function by acting as a sponge of miR-377-3p to regulate JaK2 expression in esophageal cancer. This evidence concerns the gene JAK2 and esophageal cancer.