Of note, Western blot results presented that the treatment of exosome could promote JAK2 protein level in EC9706 and KYSE30 cells, and the upregulation of miR-377-3p reversed the effect (Figure 6H) In addition, there was an inverse correlation between JAK2 and miR-377-3p or circ_0000337 in esophageal cancer tissues (Figures 6I,J), suggesting that JAK2 could be positively regulated by exosomal circ_0000337/miR-377-3p. The gene discussed is JAK2; the disease is esophageal cancer.