Together with the survival data from CIBERSORT’s predictions, these data suggest that if CD8 T cells can infiltrate into the ESCC tumors, the CD8 T cells can respond positively and promote a survival benefit, whereas CD8 T cells are likely to be dysfunctional in EAC and do not have a significant correlation with survival. The gene discussed is CD8A; the disease is esophageal squamous cell carcinoma.