Although EGFR overexpression is observed in > 90% of HNSCC (Dassonville et al., 1993; Rubin Grandis et al., 1996) and is associated with an unfavorable clinical outcome (Rubin Grandis et al., 1998; Ang et al., 2004) the correlation with response to treatment is inconsistent (Vermorken et al., 2007). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.