CDC42 and neoplasm: Ras homolog family member A (RhoA) and CDC42 are key downstream components of ARHGAP correlating with leukocyte transendothelial, chemokine signaling pathway, and T-cell receptor signaling pathway in enriched ARHGAP family genes PPI network, indicating that the ARHGAP family genes are involved in several immune pathways in immune-related tumor microenvironment in BCa (Figure 4A).