We have demonstrated that the ARHGAP family genes correlated with an immuno-related tumor-promoting microenvironment through bioinformatic analysis, and our in vivo and in vitro experiments validated that ARHGAP5, ARHGAP17, and ARHGAP24 promoted the proliferation, migration, and metastasis phenotype of BCa cells. The gene discussed is ARHGAP17; the disease is neoplasm.