Interestingly, Filamin-A, an actin cross-linking protein that binds ROCK and PAK-1 (Ohta et al., 2006), also interacts with CD4, CCR5, and CXCR4 (Jiménez-Baranda et al., 2007), and this interaction was shown to be required for Env-mediated RhoA activation, Cofilin phosphorylation, and efficient HIV-1 infection. This evidence concerns the gene CFL1 and HIV-1 infection.