After dividing these samples into two clusters based on the expression level of ER stress related genes, the survival analysis show the prognosis of IDH wildtype GBM patients in two clusters tend to be different although the difference was not statistically significant in TCGA dataset (Supplementary Figures 1G,H, P = 0.13 and P = 0.03 for TCGA and CGGA dataset, respectively). Here, IDH1 is linked to glioblastoma.