NLRC5 and cancer: Single-cell RNA sequencing analysis from two melanoma datasets, including GSE72056 and GSE115978, showed that NLRC5 is expressed in not only immune cells, including macrophages, NK cells, T cells, and B cells, but also in endothelial cells, CAFs (cancer-associated fibroblasts), and malignant melanoma cells in melanoma samples (Figures 1A,B).