There is no significant difference in the mortality between the agranulocytosis group and the non-agranulocytosis group (55.6 vs. 55.6%), and there is no difference in composition ratio of age, sex, PEEP, and whether or not complicated by MODS, but there are differences in total hospitalization time, VIS, PIP, CRP, and PCT values. The gene discussed is CRP; the disease is Absence of circulating granulocytes.